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The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 437-442 doi: 10.1007/s11684-009-0074-x

Abstract: Rs5065 NPPA gene polymorphism leads to the translation of NPPA with two additional arginines and hasThe purpose of the present study was to investigate the relationship between the rs5065 NPPA gene polymorphismWe genotyped the single nucleotide polymorphism (SNP) rs5065 NPPA in the human NPPA gene in 1861 sex-Our results suggest that the C allele of rs5065 NPPA gene polymorphism may be associated with the risk

Keywords： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism     single nucleotide    

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FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 295-305 doi: 10.1007/s11684-021-0857-2

Abstract: The FMO3 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort

Keywords： chronic heart failure     trimethylamine-N-oxide     flavin monooxygenase 3     single nucleotide polymorphism    

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Microbial community structure in different wastewater treatment processes characterized by single-strandconformation polymorphism (SSCP) technique

ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 116-121 doi: 10.1007/s11783-008-0018-8

Abstract: wastewater treatment pro cesses were studied by a culture-independent genetic fingerprinting technique single-strandconformation polymorphism (SSCP).

Keywords： technique single-strand     proportion     bioreactor     community diversity     fingerprinting technique    

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Base editing in pigs for precision breeding

Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 161-170 doi: 10.15302/J-FASE-2019308

Abstract: Single nucleotide polymorphisms (SNPs) are a dominant type of genetic variation among individual pigsPrecision single base substitution provides a strategy for accurate genetic improvement in pig productionediting has recently been developed as the latest gene-editing tool that can directly make changes in single

Keywords： base editing     genetic improvement     pigs     single nucleotide polymorphisms    

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Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome

Guangbiao Zhou, Xinchun Zhao

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 236-238 doi: 10.1007/s11684-017-0611-y

Abstract: Province of China, and 47% to 1.7% of HCCs from the Chinese mainland and other countries harbored the nucleotide

Keywords： genomic signature     carcinogen     aristolochic acid     tobacco smoke     vinyl chloride     hepatocellular carcinoma    

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Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection Review

Jiachao Zhang,Rob Knight,

Engineering 2023, Volume 20, Issue 1,   Pages 96-102 doi: 10.1016/j.eng.2021.11.018

Abstract:

Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.

Keywords： Gut microbiota     Genomic mutations     Adaptive evolution     Purifying selection     Single-nucleotide variants    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract:

It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-inducedThe purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associatedIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsusing polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP).We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 37-44 doi: 10.1007/s11705-009-0294-2

Abstract: Polymorphism is a widespread phenomenon observed in more than half of all drug substances.

Keywords： development     Polymorphism     elucidation     controversial     relationship    

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A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 321-330 doi: 10.15302/J-FASE-2014037

Abstract: Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated with one or multiple milk production traits in the Chinese Holstein population. Of these, 38 significant SNPs detected with high confidence by both L1-TDT and MMRA methods were selected to further mine potential key genes affecting milk yield and milk composition. By blasting the flanking sequences of these 38 SNPs with the bovine genome sequence combined with comparative genomics analysis, 26 genes were found to contain or be near to such SNPs. Among them, the gene is merely 87 bp away from the significant SNP, Hapmap30383-BTC-005848. Hence, we report herein genotype-phenotype associations to further validate the genetic effects of the gene. By pooled DNA sequencing of 14 unrelated Holstein sires, a total of 18 with seven novel SNPs were identified. Among them, nine SNPs were in the 5′ regulatory region, one in exon 6 and the other in the 3′ UTR and 3′ regulatory region. A total of nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for association with five milk production traits in an independent resource population. The results showed that these SNPs were statistically significant for more than two traits [ <(0.0001-0.0267)]. In addition, mRNA expression analyses revealed that was ubiquitous in eight different tissues, with a relatively higher expression level in the mammary gland than in other tissues. These findings, therefore, provide strong evidence for association of variants with milk yield and milk composition traits and may be applied in Chinese Holstein breeding programs.

Keywords： GWAS     functional annotation     Chinese Holstein     milk production traits     C14H8orf33 gene     single nucleotide    

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Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 101-105 doi: 10.1007/s11684-010-0017-6

Abstract: This study aims to investigate the genetic association between the polymorphism of cytosolic phospholipasepolymerase chain reaction-based ligase detection reaction (PCR-LDR) was applied to detect the genotype ten singlenucleotide polymorphisms (SNPs) of cPLA2 family genes among 201 pedigrees consisting of fathers, mothers

Keywords： schizophrenia     cytosolic phospholipase A2     ligase detection reaction     polymorphism    

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Polymorphism and crystal transformation of penicillin sulfoxide

Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4,   Pages 442-447 doi: 10.1007/s11705-011-1140-x

Abstract: Penicillin sulfoxide is the intermediate for the synthesis of 7-amino-3-desacetoxycephalosporanic acid which is one of the most important nucleuses of cephalosporin antibiotic. In this contribution, two crystal structures of penicillin sulfoxide (forms I and II) were determined by X-ray diffraction, and their thermotropic properties were investigated by differential scanning calorimetry (DSC). Furthermore, the transformation of form II to form I was studied quantitatively by Raman spectroscopy, and its rates at different temperatures were determined. The results indicate that penicillin sulfoxide is more stable as form I, and the temperature plays an important role in the crystal transformation.

Keywords： penicillin sulfoxide     crystallization     polymorphism     crystal transformation     Raman spectroscopy    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 178-181 doi: 10.1007/s11684-008-0033-y

Abstract: To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and bloodBy using PCR-RFLP, the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertensionThe distribution of eNOS Glu298Asp polymorphism had no significant difference between different bloodrisk of hypertension in individuals with serum TC above 5.4 mmol/L ( = 0.03, = 2.65). eNOS Glu298Asp polymorphism
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Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism andPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotypeGNB C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects.No evidence was found to suggest an association between GNB C825T polymorphism and hypertension in the

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

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Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 320-326 doi: 10.1007/s11684-007-0062-y

Abstract: The aim of this study was to explore the association of the genetic polymorphism of and with the susceptibilityThe single nucleotide polymorphisms (SNPs, rs2854451, rs3738047, rs2234922 and rs1051741) of gene andIt was also found that there were potential interactions between alcohol consumption and the polymorphismThe genetic polymorphism in may be associated with the risk of CBP in the Chinese occupational populationand further research is needed for the association between the genetic polymorphism in and the susceptibility

Keywords： case-control     rs2854451     regression analysis     haplotype     further research    

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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract: In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in

Keywords： direct-acting antiviral (DAA)     nucleotide polymerase inhibitors     protease inhibitors    

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Title Author Date Type Operation

The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Journal Article

FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population

Journal Article

Microbial community structure in different wastewater treatment processes characterized by single-strandconformation polymorphism (SSCP) technique

ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan

Journal Article

Base editing in pigs for precision breeding

Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO

Journal Article

Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome

Guangbiao Zhou, Xinchun Zhao

Journal Article

Genomic Mutations within the Host Microbiome: Adaptive Evolution or Purifying Selection

Jiachao Zhang,Rob Knight,

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Journal Article

A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Journal Article

Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Journal Article

Polymorphism and crystal transformation of penicillin sulfoxide

Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG

Journal Article

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile

TANG Zhongzhi, LI Junyao, YANG Jianhong

Journal Article

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Journal Article

Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Journal Article